Michael Shanks is now the second Second Labour MP in Westminster
The former teacher will now swap the classroom for the Commons.
He won with 17,845 votes or 58.4 per cent of the vote share.
Katy Loudon of the SNP scored 8399 votes while Thomas Kerr of the Conservatives won 1192.
Sir Keri Starmer says Labour will deliver
Sir Keir Starmer, the leader of the Labour party, has said they are ready to deliver after tonight’s win.
Mr Starmer said: “This is a seismic result.
“People in Rutherglen and Hamilton West have sent a clear message – it is time for change.
“And it is clear they believe that this changed Labour Party can deliver it.
“I have always said that winning back the trust of people in Scotland is essential.
“Tonight’s victory is the culmination of three and a half years of hard work in years of hard work and humility on that journey.
“I am grateful to everyone who has put their faith in us today – we will work every day to repay it.
“Voters across Scotland and across Britain want a government determined to deliver for working people, with a proper plan to rebuild our country.
“They want to move on from two SNP and Tory governments that offer only more division, more chaos and more infighting.
“The country deserves a government firmly on their side and focused on their priorities – and Labour will deliver that for them.”
Humza Yousaf reacts
The First Minister has reacted after the SNP lost the Rutherglen and Hamilton West by-election.
Humza Yousaf tweeted: “A disappointing night for the SNP.
“I want to thank our exceptional candidate @KatyLoudonSNP and our activists for their incredible efforts.
“Let me also congratulate Michael Shanks on being elected.
“Circumstances of this by-election were always very difficult for us.
“Collapse in the Tory vote, which went straight to Labour, also a significant factor.
“We lost this seat in 2017, and like 2019 we can win this seat back.
“However, we will reflect on what we have to do to regain the trust of the people of Rutherglen and Hamilton West.”