The new male pill is a hormone-free drug, unlike the female pill.
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Previous studies dating back more than 90 years have shown that depriving mice, rats and monkeys of vitamin A can cause infertility.
Experts from biopharmaceutical company YourChoice Therapeutics said that preclinical studies showed YCT-529 was “99 per cent effective and 100 per cent reversible with no side effects”.
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The company said that previous versions of the male pill have attempted to suppress the male sex hormone testosterone to prevent sperm production, but this does not stop sperm production completely and has been linked to some complications.
Now, 16 men are testing the hormone-free pill in the UK. The phase 1 trial is being conducted by Quotient Sciences, a drug development company based in the English city of Nottingham.
“The last innovation in contraception was the birth control pill for women, and that’s more than 60 years ago,” said Gunda Georg, regents professor at the University of Minnesota’s College of Pharmacy, who developed the pill.
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“The world is ready for a male contraceptive agent, and delivering one that’s hormone-free is simply the right thing to do given what we know about the side effects women have endured for decades from the pill,” Georg said.
“We consciously chose to inhibit the vitamin A signalling pathway in the testis because nearly 100 years of research has validated this pathway and shows that infertility can be reversed easily,” she added.
“Our preclinical data is strong, showing that YCT-529 was 99 per cent effective in preventing mouse pregnancies and decreasing monkey sperm counts after two weeks of dosing. YCT-529 has also showed a strong safety profile, and full reversibility in mice and monkeys once treatment ended.”
The dearth of options reinforces the centuries-old view that pregnancy prevention is ‘a woman’s responsibility’
Akash Bakshi, co-founder and chief executive of YourChoice Therapeutics, noted that YCT-529 blocks a protein – not hormones – to prevent sperm production.
“We believe this will be more attractive to men, most of whom view pregnancy prevention as a shared responsibility even despite today’s limited contraceptive options, which are permanent or only moderately effective,” he said.
“The dearth of options reinforces the centuries-old view that pregnancy prevention is ‘a woman’s responsibility’. It’s not, and we’re committed to advancing the first hormone-free birth control pill for men that’s effective, convenient and temporary.”